PubChem PUG REST

Power User Gateway REST interface to PubChem - a database of chemical molecules and their activities against biological assays. Provides access to compound structures, properties, synonyms, and bioactivities.

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Base URL: https://pubchem.ncbi.nlm.nih.gov/rest/pug
Auth: unknown
Endpoints: 17
Reachable: yes
CORS: unknown
Last checked: 2026-03-14 16:09:20.722574

Links

Homepage: https://pubchem.ncbi.nlm.nih.gov/
API Base: https://pubchem.ncbi.nlm.nih.gov/rest/pug

100.0%

Uptime (7d)

573ms

Avg latency (7d)

36

Probes (7d)

Latency (7d)

Success Rate (7d)

Topics

CHEMISTRY, GOVERNMENT, SCIENCE

Endpoints

Method Path Summary Auth Last Status Latency
GET /assay/aid/{aid}/summary Get bioassay summary by AID none 200 606ms
GET /compound/cid/{cid}/cids/{format} Get CIDs by CID (identity) — 200 343ms
GET /compound/cid/{cid}/property/{properties} Get compound properties by CID none 200 466ms
GET /compound/cid/{cid}/property/{properties}/{format} Get compound properties by CID — 200 395ms
GET /compound/cid/{cid}/record/{format} Get full compound record by CID — 200 451ms
GET /compound/cid/{cid}/sdf Get compound SDF by CID none 200 456ms
GET /compound/cid/{cid}/synonyms Get synonyms for a compound none 200 412ms
GET /compound/cid/{cid}/synonyms/{format} Get synonyms by CID — 200 564ms
GET /compound/fastidentity/smiles/{smiles}/cids/{format} Identity search by SMILES — 200 776ms
GET /compound/fastsubstructure/smiles/{smiles}/cids/{format} Substructure search by SMILES — 200 1111ms
GET /compound/inchikey/{inchikey}/cids Get CIDs by InChIKey none 200 522ms
GET /compound/name/{name}/cids Get CIDs by compound name none 200 346ms
GET /compound/name/{name}/cids/{format} Get CIDs by compound name — 200 521ms
GET /compound/smiles/{smiles}/cids Get CIDs by SMILES none 200 724ms
GET /compound/smiles/{smiles}/cids/{format} Get CIDs by SMILES — 200 646ms
GET /source/{source_name}/{category} List records by source none 400 347ms
GET /substance/sid/{sid}/cids Get CIDs for a substance none 200 380ms